The First Presentation of Localized Scleroderma at Birth: Scleroderma as a Differential Diagnosis of Congenital Skin Lesion

Abstract Localized scleroderma is an uncommon autoimmune disease characterized by fibrosis of the skin and underlying tissue without involvement blood vessels or internal organs. It usually affects children during later childhood, early presentation localized infancy rare. In current study, we report a child with scleroderma-related presentations occurring at birth. A 2-day-old male neonate presented firm, erythematous, slightly pigmented plaque on his left thigh, leading to change in diameter affected foot contracture knee. At age 7 months, he was referred our rheumatology clinic normal growth development. Laboratory studies, including urine high-performance liquid chromatography assay, antinuclear antibodies, antitopoisomerase I, rheumatic factor, were range. No signs ocular noted ophthalmological consultation. Skin biopsy showed mild acanthosis collagen bundles, which replaced fat around sweat glands. final diagnosis made. Treatment started oral prednisolone, methotrexate (MTX), colchicine. The lesion stopped progressing after 3 months treatment. Steroid then tapered over 6 while MTX colchicine continued for 2 years. rare disease, but it should be considered as differential infants erythematous firm lesions their body birth because treatment can prevent future complications.